Caffeine is the most widely psychoactive substance ingested in the world. It can be originated from both plants and synthetic sources. In the US, more than 85% of the adults consume a variety of caffeinated beverages, dietary supplements, and food products regularly, among them, average consumption is more than 200 mg of caffeine per day [1,2]. Some of the effects of caffeine can be listed as follows: stimulant effect , alertness effect , procognitive effects , and many more... When it is consumed, caffeine concentration in the body peaks about 1 hour after ingestion .
Ok, why do you drink caffeine? Let’s look at its neuropharmacology. Caffeine acts as an antagonist at adenosine receptors, therefore it blocks endogenous adenosine . Since caffeine inhibits the adenosine, it produces a range of effects opposite those of adenosine, including the behavioral stimulant effects . One of those is stimulating dopaminergic activity. Normally, there is a negative modulatory effect of adenosine at dopamine receptors. When caffeine blocks it, dopamine release at nucleus accumbens (a brain region associated with reward mechanisms of many drugs of dependence, including amphetamines and cocaine) is increased . It seems that increased dopamine release may be a specific neuropharmacological mechanism underlying the addictive potential of caffeine.
Yes, although several studies showed that there is an addictive potential of caffeine and despite a lot of pressure from doctors, caffeine addiction has not yet been classified as a mental disorder by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). However, some caffeine related problems had attention to be included in DSM-5. For example, both caffeine withdrawal and caffeine overdose did make it into the latest diagnostic manual. Caffeine use disorder is considered a condition for further study in DSM-5. The closely related caffeine dependence syndrome is a recognized disorder in The WHO’s “The International Statistical Classification of Diseases and Related Health Problems” (ICD-10) .
I think, coffee is addictive to me, thereby caffeine 😊. I have many words to say, maybe in the future.